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The NCAA is allowed to randomly drug test Division 1 college football players. Many don't know what is a banned substance and what is not. There is no actual list but players are still responsible for knowing about it. This is hard for athletes because there's so many substances that are not well known. It is important to report any medicines or supplements to the athletic trainer no matter how small amount you are taking, like an inhaler for asthma. Taking creatine is okay but caffeine in large doses would fail the test. Diet supplements will also fail the test and even some flavors of Vitamin Water can fail a test. If a football player fails the random test, they will lose their eligibility and will possibly lose their scholarship. The NCAA website has good information about drug testing and how they do it.
http://www.ncaa.org/wps/wcm/connect/53e6f4804e0b8a129949f91ad6fc8b25/2009-10+Banned+Drug+Classes.pdf?MOD=AJPERES&CACHEID=53e6f4804e0b8a129949f91ad6fc8b25
http://www.sherdog.net/forums/f15/good-faq-ncaa-banned-substances-answers-why-muscle-milk-banned-686353/